Gene length as a biological timer to establish temporal transcriptional regulation.

ABSTRACT: Transcriptional timing is inherently influenced by gene length, thus providing a mechanism for temporal regulation of gene expression. While gene size has been shown to be important for the expression timing of specific genes during early development, whether it plays a role in the timing of other global gene expression programs has not been extensively explored. Here, we investigate the role of gene length during the early transcriptional response of human fibroblasts to serum stimulation. Using the nascent sequencing techniques Bru-seq and BruUV-seq, we identified immediate genome-wide transcriptional changes following serum stimulation that were linked to rapid activation of enhancer elements. We identified 873 significantly induced and 209 significantly repressed genes. Variations in g

SUBMITTER: Kirkconnell KS 

PROVIDER: S-EPMC5323030 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature