Pathogenesis of pancreatic cancer exosome-induced lipolysis in adipose tissue.

ABSTRACT:

Background and objectives

New-onset diabetes and concomitant weight loss occurring several months before the clinical presentation of pancreatic cancer (PC) appear to be paraneoplastic phenomena caused by tumour-secreted products. Our recent findings have shown exosomal adrenomedullin (AM) is important in development of diabetes in PC. Adipose tissue lipolysis might explain early onset weight loss in PC. We hypothesise that lipolysis-inducing cargo is carried in exosomes shed by PC and is responsible for the paraneoplastic effects. Therefore, in this study we investigate if exosomes secreted by PC induce lipolysis in adipocytes and explore the role of AM in PC-exosomes as the mediator of this lipolysis.

Design

Exosomes from patient-derived cell lines and from plasma of patie

SUBMITTER: Sagar G 

PROVIDER: S-EPMC5323066 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature