Predictive and prognostic value of preoperative serum tumor markers in resectable adenosqamous lung carcinoma.

ABSTRACT:

Background

Adenosquamous carcinoma is a rare and aggressive form of lung cancer. The prognostic and predictive value of preoperative serum tumor markers and frequency of EGFR mutations in adenosquamous lung carcinoma are unclear.

Methods

We retrospectively analyzed data and samples collected from 106 radically resected adenosquamous lung carcinoma patients with pathological stage I-IIIA between 2008 and 2013. Correlations between serum tumor marker levels and EGFR mutations as well as survival parameters were analyzed and prognostic factors were identified.

Results

Of the 106 adenosquamous lung carcinoma patients, 29 (27.4%) harbored EGFR mutations. By univariate analysis, advanced clinical stage (P = 0.009 for disease-free survival [DFS]; P = 0.046 for overall surviv

SUBMITTER: Zhi Q 

PROVIDER: S-EPMC5323117 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature