Bone marrow adipocytes promote the Warburg phenotype in metastatic prostate tumors via HIF-1α activation.

ABSTRACT: Metabolic adaptation is increasingly recognized as a key factor in tumor progression, yet its involvement in metastatic bone disease is not understood. Bone is as an adipocyte-rich organ, and a major site of metastasis from prostate cancer. Bone marrow adipocytes are metabolically active cells capable of shaping tumor metabolism via lipolysis and lipid transfer. In this study, using in vitro and in vivo models of marrow adiposity, we demonstrate that marrow fat cells promote Warburg phenotype in metastatic prostate cancer cells. We show increased expression of glycolytic enzymes, increased lactate production, and decreased mitochondrial oxidative phosphorylation in tumor cells exposed to adipocytes that require paracrine signaling between the two cell types. We also reveal that prostate ca

SUBMITTER: Diedrich JD 

PROVIDER: S-EPMC5323121 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature