Cancer stem cell markers predict a poor prognosis in renal cell carcinoma: a meta-analysis.

ABSTRACT:

Background

Relevant markers of CSCs may serve as prognostic biomarkers of RCC. However, their actual prognostic significance remains inconclusive. Thus, a meta-analysis was performed to reevaluate the association of CSCs-relevant markers (CXCR4, CD133, CD44, CD105) expression with RCC prognosis more precisely.

Methods

PubMed and Embase were searched to look for eligible studies. The pooled hazard ratios (HR) with 95% confidence intervals (95% CI) were used to reassess the association of CSCs markers expression and RCC prognosis of overall survival (OS), cancer-specific survival (CSS), disease-free survival (DFS), and progression-free survival (PFS).

Results

There were 25 relevant articles, encompassing 2673 RCC patients, eligible for meta-analysis. Overall pooled anal

SUBMITTER: Cheng B 

PROVIDER: S-EPMC5323198 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature