CtDNA dynamics: a novel indicator to track resistance in metastatic breast cancer treated with anti-HER2 therapy.

ABSTRACT:

Background

Most studies utilizing circulating tumor DNA (ctDNA) to monitor disease interrogated only one or a few genes and failed to develop workable criteria to inform clinical practice. We evaluated the feasibility of detecting resistance to anti-HER2 therapy by serial gene-panel ctDNA sequencing.

Results

Primary therapeutic resistance was identified in 6 out of 14 patients with events of progressive disease. For this subset comparison of pre- and post-treatment ctDNA assay results revealed that HER2 amplification concurred with disease progression (4/6, 66.7%). Mutations in TP53 (3/6, 50.0%) and genes implicated in the PI3K/mTOR pathway (3/6, 50.0%) were also dominant markers of resistance. Together, resistance to HER2 blockade should be indicated during treatment if any

SUBMITTER: Ma F 

PROVIDER: S-EPMC5323211 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature