Patient-derived xenograft models of colorectal cancer in pre-clinical research: a systematic review.

ABSTRACT:

Aims

We sought to objectively assess the internal and external validity of patient-derived xenograft (PDX) models as a platform in pre-clinical research into colorectal cancer (CRC). Metastatic disease is the most common cause of death from CRC, and despite significant research, the results of current combination chemotherapy and targeted therapies have been underwhelming for most of this patient group. One of the key factors limiting the success of translational CRC research is the biologically inaccurate models in which new therapies are developed.

Methods

We used the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) checklist and SYRCLE (Systematic Review Centre for Laboratory animal Experimentation) guidelines to search Ovid MEDLINE and Embase d

SUBMITTER: Brown KM 

PROVIDER: S-EPMC5323228 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature