Natural history of pure autonomic failure: A United States prospective cohort.

ABSTRACT:

Objective

To define the clinical features and biomarkers that predict which patients with pure autonomic failure will develop Parkinson disease, dementia with Lewy bodies, or multiple system atrophy.

Methods

One hundred patients who presented with pure autonomic failure were recruited at 5 medical centers in the United States. Seventy-four patients agreed to be followed prospectively. Patients underwent clinical evaluations including neurological rating scales, sleep questionnaires, smell test, and sympathetic and parasympathetic cardiovascular autonomic function tests.

Results

At enrollment, patients were 68 ± 12 years old (median ± interquartile range) and had had autonomic failure for 5 ± 7 years. Within 4 years of follow-up, 25 of 74 subjects (34%) developed demen

SUBMITTER: Kaufmann H 

PROVIDER: S-EPMC5323269 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature