Brown adipose tissue does not seem to mediate metabolic adaptation to overfeeding in men.

ABSTRACT:

Objective

Brown adipose tissue (BAT) generates heat in response to cold, and low BAT activity has been linked to obesity. However, recent studies were inconclusive as to whether BAT is involved in diet-induced thermogenesis and mitigates weight gain from prolonged overeating. Therefore, this study investigated whether BAT activity is related to metabolic adaptation arising from 8 weeks of overfeeding in humans.

Methods

Fourteen men (aged 24 ± 3 years, BMI 24.5 ± 1.6 kg/m² ) were overfed by 40% for 8 weeks. Before and after, energy expenditure and metabolic adaptation were measured by whole-room respiratory calorimetry. A marker of BAT activity was measured using infrared imaging of the supraclavicular BAT depot.

Results

At the end of 8 weeks of overfeeding,

SUBMITTER: Peterson CM 

PROVIDER: S-EPMC5323278 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature