Nonalcoholic fatty liver disease and measures of early brain health in middle-aged adults: The CARDIA study.

ABSTRACT:

Objective

To assess associations between nonalcoholic fatty liver disease (NAFLD) and measures of brain health in a population-based sample of adults.

Methods

Participants from the CARDIA study (Y25 exam; age 43-55 years) with concurrent computed tomography quantification of liver fat, visceral adipose tissue (VAT), and brain magnetic resonance (MR) images were included (n = 505). NAFLD was identified after exclusion of other causes of liver fat. Total tissue volume (TTV) and gray matter cerebral blood flow (GM-CBF) were estimated using 3T brain MR images.

Results

NAFLD prevalence was 18%. NAFLD was associated with lower TTV and GM-CBF after adjusting for intracranial volume, demographics, and health behaviors (P < 0.04 for all). In models with additional adjustment f

SUBMITTER: VanWagner LB 

PROVIDER: S-EPMC5323279 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature