A pilot investigation of the impact of smoking cessation on biological age.

ABSTRACT:

Background and objectives

Smoking is known to increase biological age. However, whether this process is reversible through smoking cessation is not known. In this pilot study, we attempt to determine whether smoking cessation reduces biological age.

Methods

We conducted regression analyses of methylation data from 22 subjects, as they entered and exited inpatient substance use treatment, to determine change in biological age, as indicated by the deviation of their methylomic age from chronological age across two time points.

Results

We found that, as compared to those subjects who did not stop smoking, subjects who significantly decreased their smoking consumption over a 1 month time period exhibited a marked reduction in methylomic age.

Conclusion

The rapid an

SUBMITTER: Lei MK 

PROVIDER: S-EPMC5323361 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature