Mechanisms of Mas1 Receptor-Mediated Signaling in the Vascular Endothelium.

ABSTRACT:

Objective

Angiotensin II (AngII) has been shown to regulate angiogenesis and at high pathophysiological doses to cause vasoconstriction through the AngII receptor type 1. Angiotensin 1 to 7 (Ang-(1-7)) acting through the Mas1 receptor can act antagonistically to high pathophysiological levels of AngII by inducing vasodilation, whereas the effects of Ang-(1-7) signaling on angiogenesis are less defined. To complicate the matter, there is growing evidence that a subpressor dose of AngII produces phenotypes similar to Ang-(1-7).

Approach and results

This study shows that low-dose Ang-(1-7), acting through the Mas1 receptor, promotes angiogenesis and vasodilation similar to a low, subpressor dose of AngII acting through AngII receptor type 1. In addition, we show through in vitr

SUBMITTER: Hoffmann BR 

PROVIDER: S-EPMC5323371 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature