The Ih Channel Gene Promotes Synaptic Transmission and Coordinated Movement in Drosophila melanogaster.

ABSTRACT: Hyperpolarization-activated cyclic nucleotide-gated "HCN" channels, which underlie the hyperpolarization-activated current (I_h), have been proposed to play diverse roles in neurons. The presynaptic HCN channel is thought to both promote and inhibit neurotransmitter release from synapses, depending upon its interactions with other presynaptic ion channels. In larvae of Drosophila melanogaster, inhibition of the presynaptic HCN channel by the drug ZD7288 reduces the enhancement of neurotransmitter release at motor terminals by serotonin but this drug has no effect on basal neurotransmitter release, implying that the channel does not contribute to firing under basal conditions. Here, we show that genetic disruption of the sole HCN gene (Ih) reduces the amplitude of th

SUBMITTER: Hegle AP 

PROVIDER: S-EPMC5323408 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature