Efficacy of fixed-dosing aflibercept for treating polypoidal choroidal vasculopathy: 1-year results of the VAULT study.

ABSTRACT:

Purpose

To investigate fixed-dosing aflibercept for treating polypoidal choroidal vasculopathy (PCV).

Methods

This phase IV, prospective, single-arm, interventional case series was conducted in eight centers. Forty treatment-naïve PCV patients were administered three monthly doses of intravitreal aflibercept (2.0 mg) and an injection every 2 months thereafter. Best-corrected visual acuity (BCVA) and central subfield macular thickness (CSMT) were measured at each visit. Fluorescein and indocyanine green angiography (ICGA) were performed at baseline, 3 and 12 months. The primary outcome measure was the proportion of patients who maintained BCVA (<15 letters loss) at 12 months. Changes in BCVA, macular appearance, and polypoidal lesion appearance were also examined.

Results<

SUBMITTER: Lee JE 

PROVIDER: S-EPMC5323470 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature