Divergent effects of a designer natriuretic peptide CD-NP in the regulation of adipose tissue and metabolism.

ABSTRACT:

Objective

Obesity is defined as an abnormal increase in white adipose tissue (WAT) and is a major risk factor for type 2 diabetes and cardiovascular disease. Brown adipose tissue (BAT) dissipates energy and correlates with leanness. Natriuretic peptides have been shown to be beneficial for brown adipocyte differentiation and browning of WAT.

Methods

Here, we investigated the effects of an optimized designer natriuretic peptide (CD-NP) on murine adipose tissues in vitro and in vivo.

Results

In murine brown and white adipocytes, CD-NP activated cGMP production, promoted adipogenesis, and increased thermogenic markers. Consequently, mice treated for 10 days with CD-NP exhibited increased "browning" of WAT. To study CD-NP effects on diet-induced obesity (DIO

SUBMITTER: Glode A 

PROVIDER: S-EPMC5323888 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature