Comparison of nanoparticular hydroxyapatite pastes of different particle content and size in a novel scapula defect model.

ABSTRACT: Nanocrystalline hydroxyapatite (HA) has good biocompatibility and the potential to support bone formation. It represents a promising alternative to autologous bone grafting, which is considered the current gold standard for the treatment of low weight bearing bone defects. The purpose of this study was to compare three bone substitute pastes of different HA content and particle size with autologous bone and empty defects, at two time points (6 and 12 months) in an ovine scapula drillhole model using micro-CT, histology and histomorphometry evaluation. The nHA-LC (38% HA content) paste supported bone formation with a high defect bridging-rate. Compared to nHA-LC, Ostim^® (35% HA content) showed less and smaller particle agglomerates but also a reduced defect bridging-rate due to i

SUBMITTER: Hruschka V 

PROVIDER: S-EPMC5324075 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature