The Roles of Dopamine D2 Receptor in the Social Hierarchy of Rodents and Primates.

ABSTRACT: Dopamine (DA) plays significant roles in regulation of social behavior. In social groups of humans and other animals, social hierarchy exists, which is determined by several behavioral characteristics such as aggression and impulsivity as well as social affiliations. In this study, we investigated the effects of pharmacological blockade of DA D2 receptor on social hierarchy of Japanese macaque and mouse social groups. We found acute administration of the D2 antagonist, sulpiride, in socially housed Japanese macaques attenuated social dominance when the drug was given to high social class macaques. A similar attenuation of social dominance was observed in high social class mice with D2 antagonist administration. In contrast, D2 antagonist administration in low social class macaque resulted

SUBMITTER: Yamaguchi Y 

PROVIDER: S-EPMC5324123 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature