Increased 4R tau expression and behavioural changes in a novel MAPT-N296H genomic mouse model of tauopathy.

ABSTRACT: The microtubule-associated protein tau is implicated in various neurodegenerative diseases including Alzheimer's disease, progressive supranuclear palsy and corticobasal degeneration, which are characterized by intracellular accumulation of hyperphosphorylated tau. Mutations in the tau gene MAPT cause frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17). In the human central nervous system, six tau isoforms are expressed, and imbalances in tau isoform ratios are associated with pathology. To date, few animal models of tauopathy allow for the potential influence of these protein isoforms, relying instead on cDNA-based transgene expression. Using the P1-derived artificial chromosome (PAC) technology, we created mouse lines expressing all six tau isoforms from the human

SUBMITTER: Wobst HJ 

PROVIDER: S-EPMC5324134 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature