Exploratory bioinformatics investigation reveals importance of "junk" DNA in early embryo development.

ABSTRACT:

Background

Instead of testing predefined hypotheses, the goal of exploratory data analysis (EDA) is to find what data can tell us. Following this strategy, we re-analyzed a large body of genomic data to study the complex gene regulation in mouse pre-implantation development (PD).

Results

Starting with a single-cell RNA-seq dataset consisting of 259 mouse embryonic cells derived from zygote to blastocyst stages, we reconstructed the temporal and spatial gene expression pattern during PD. The dynamics of gene expression can be partially explained by the enrichment of transposable elements in gene promoters and the similarity of expression profiles with those of corresponding transposons. Long Terminal Repeats (LTRs) are associated with transient, strong induction of many nearb

SUBMITTER: Ge SX 

PROVIDER: S-EPMC5324221 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature