SOFA and mortality endpoints in randomized controlled trials: a systematic review and meta-regression analysis.

ABSTRACT:

Background

The sequential organ failure assessment score (SOFA) is increasingly used as an endpoint in intensive care randomized controlled trials (RCTs). Although serially measured SOFA is independently associated with mortality in observational cohorts, the association between treatment effects on SOFA vs. effects on mortality has not yet been quantified in RCTs. The aim of this study was to quantify the relationship between SOFA and mortality in RCTs and to identify which SOFA derivative best reflects between-group mortality differences.

Methods

The review protocol was prospectively registered (Prospero CRD42016034014). We performed a literature search (up to May 1, 2016) for RCTs reporting both SOFA and mortality, and analyzed between-group differences in these outcomes.

SUBMITTER: de Grooth HJ 

PROVIDER: S-EPMC5324238 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature