Meta-aligner: long-read alignment based on genome statistics.

ABSTRACT:

Background

Current development of sequencing technologies is towards generating longer and noisier reads. Evidently, accurate alignment of these reads play an important role in any downstream analysis. Similarly, reducing the overall cost of sequencing is related to the time consumption of the aligner. The tradeoff between accuracy and speed is the main challenge in designing long read aligners.

Results

We propose Meta-aligner which aligns long and very long reads to the reference genome very efficiently and accurately. Meta-aligner incorporates available short/long aligners as subcomponents and uses statistics from the reference genome to increase the performance. Meta-aligner estimates statistics from reads and the reference genome automatically. Meta-aligner is implemente

SUBMITTER: Nashta-Ali D 

PROVIDER: S-EPMC5324271 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature