In vitro evidence of efficacy and safety of a polymerized cat dander extract for allergen immunotherapy.

ABSTRACT:

Background

Allergy to cat epithelia is highly prevalent, being the major recommendation for allergy sufferers its avoidance. However, this is not always feasible. Allergen specific immunotherapy is therefore recommended for these patients. The use of polymerized allergen extracts, allergoids, would allow to achieve the high allergen doses suggested to be effective while maintaining safety.

Results

Cat native extract and its depigmented allergoid were manufactured and biochemically and immunochemically characterized. Protein and chromatographic profiles showed significant modification of the depigmented allergoid with respect to its corresponding native extract. However, the presence of different allergens (Fel d 1, Fel d 2, Fel d 3, Fel d 4 and Fel d 7) was confirmed in the

SUBMITTER: Morales M 

PROVIDER: S-EPMC5324274 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature