Copper is a Cofactor of the Formylglycine-Generating Enzyme.

ABSTRACT: Formylglycine-generating enzyme (FGE) is an O₂ -utilizing oxidase that converts specific cysteine residues of client proteins to formylglycine. We show that Cu^I is an integral cofactor of this enzyme and binds with high affinity (K_D =of 10^-17  m) to a pair of active-site cysteines. These findings establish FGE as a novel type of copper enzyme.

SUBMITTER: Knop M 

PROVIDER: S-EPMC5324649 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature