Swine Influenza Virus (H1N2) Characterization and Transmission in Ferrets, Chile.

ABSTRACT: Phylogenetic analysis of the influenza hemagglutinin gene (HA) has suggested that commercial pigs in Chile harbor unique human seasonal H1-like influenza viruses, but further information, including characterization of these viruses, was unavailable. We isolated influenza virus (H1N2) from a swine in a backyard production farm in Central Chile and demonstrated that the HA gene was identical to that in a previous report. Its HA and neuraminidase genes were most similar to human H1 and N2 viruses from the early 1990s and internal segments were similar to influenza A(H1N1)pdm09 virus. The virus replicated efficiently in vitro and in vivo and transmitted in ferrets by respiratory droplet. Antigenically, it was distinct from other swine viruses. Hemagglutination inhibition analysis suggested tha

SUBMITTER: Bravo-Vasquez N 

PROVIDER: S-EPMC5324791 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature