Obese ZDF rats fermented resistant starch with effects on gut microbiota but no reduction in abdominal fat.

ABSTRACT:

Scope

To determine if whole-grain (WG) flour with resistant starch (RS) will produce greater fermentation than isolated RS in obese Zucker Diabetic Fatty (ZDF) rats, and whether greater fermentation results in different microbiota, reduced abdominal fat, and increased insulin sensitivity.

Methods and results

This study utilized four groups fed diets made with either isolated digestible control starch, WG control flour (6.9% RS), isolated RS-rich corn starch (25% RS), or WG corn flour (25% RS). ZDF rats fermented RS and RS-rich WG flour to greatest extent among groups. High-RS groups had increased serum glucagon-like peptide 1 (GLP-1) active. Feeding isolated RS showed greater Bacteroidetes to Firmicutes phyla among groups, and rats consuming low RS diets possessed more bacte

SUBMITTER: Goldsmith F 

PROVIDER: S-EPMC5324831 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature