Endothelial nitric oxide gene polymorphisms and their association with coronary artery disease in Tunisian population.

ABSTRACT:

Objective

By releasing mediators, like nitric oxide (NO), vascular endothelium is considered so significant in the process of atherosclerotic . In fact, the major functions of NO consist in inhibiting the activation of platelet, relaxing the muscles (vascular and smooth ones), and modulating the growth and the migration of cells (vascular and smooth ones). Therefore, this process makes the endothelial nitric oxide synthase (NOS3) considerably important because it possesses atheroprotective activity. Polymophisms, rs1808593 (10G/T) as well as rs891512 (G24943A) within NOS3 gene, play major role in the coronary artery disease (CAD) development. The aim of the study is to evaluate the relationship between the 10G/T and G24943A polymorphisms and the CAD among Tunisian individuals.

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SUBMITTER: Afef L 

PROVIDER: S-EPMC5324859 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature