Serotonin Signaling through Prefrontal Cortex 5-HT_1A Receptors during Adolescence Can Determine Baseline Mood-Related Behaviors.

ABSTRACT: Lifelong homeostatic setpoints for mood-related behaviors emerge during adolescence. Serotonin (5-HT) plays an important role in refining the formation of brain circuits during sensitive developmental periods. In rodents, the role of 5-HT_1A receptors in general and autoreceptors in particular has been characterized in anxiety. However, less is known about the role of 5-HT_1A receptors in depression-related behavior. Here, we show that whole-life suppression of heteroreceptor expression results in a broad depression-like behavioral phenotype accompanied by physiological and cellular changes within medial prefrontal cortex-dorsal raphe proper (mPFC-DRN) circuitry. These changes include increased basal 5-HT in a mPFC that is hyporesponsive to stress and decreased basal 5-

SUBMITTER: Garcia-Garcia AL 

PROVIDER: S-EPMC5325088 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature