Mannose-coated gadolinium liposomes for improved magnetic resonance imaging in acute pancreatitis.

ABSTRACT:

Background

Acute pancreatitis (AP) is an acute inflammatory condition of the pancreas. The symptoms, treatment, and prognosis of mild and severe AP are different, and severe AP is a potentially life-threatening disease with a high incidence of complications and high mortality rate. Thus, it is urgent to develop an effective approach to reliably discriminate between mild and severe AP.

Methods

We have developed novel gadolinium-diethylenetriaminepentaacetic (Gd-DTPA)-loaded mannosylated liposomes (named thereafter M-Gd-NL) that preferably target macrophages in AP. The targeting ability of M-Gd-NL toward macrophages in AP and its ability to discriminate between mild and severe AP were evaluated.

Results

The liposomes were of desired particle size (~100 nm), Gd-DTPA enca

SUBMITTER: Tian B 

PROVIDER: S-EPMC5325132 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature