Identifying microRNA panels specifically associated with hepatocellular carcinoma and its different etiologies.

ABSTRACT:

Aim

Deregulation of microRNAs (miRNAs) expression has been identified in hepatocellular carcinoma (HCC), but few results are consistent. The objective of this study is to investigate "HCC tumor type specific" and "tumor common" miRNA panels.

Methods

The authors integrate and analyze clinical, etiologic and miRNA profiles data from 9 types of solid tumors in The Cancer Genome Atlas (TCGA) and HCC data from Columbia University Medical Center (CUMC).

Results

Levels of 33 miRNAs were significant different between HCC tumor and paired non-tumor tissues (over 2-fold changes) after Bonferroni correction for multiple comparisons, and most (28 miRNAs) were down-regulated in HCC tumors. Using this panel, the authors well classified HCC tumor tissues with 4 misclassifications am

SUBMITTER: Shen J 

PROVIDER: S-EPMC5325160 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature