Expanding HIV-1 subtype B transmission networks among men who have sex with men in Poland.

ABSTRACT:

Introduction

Reconstruction of HIV transmission links allows to trace the spread and dynamics of infection and guide epidemiological interventions. The aim of this study was to characterize transmission networks among subtype B infected patients from Poland.

Material and methods

Maximum likelihood phylogenenetic trees were inferred from 966 HIV-1 subtype B protease/reverse transcriptase sequences from patients followed up in nine Polish HIV centers. Monophyletic clusters were identified using 3% within-cluster distance and 0.9 bootstrap values. Interregional links for the clusters were investigated and time from infection to onward transmission estimated using Bayesian dated MCMC phylogeny.

Results

Three hundred twenty one (33.2%) sequences formed 109 clusters, includ

SUBMITTER: Parczewski M 

PROVIDER: S-EPMC5325290 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature