Lipofuscin-associated photo-oxidative stress during fundus autofluorescence imaging.

ABSTRACT:

Purpose

Current standards and guidelines aimed at preventing retinal phototoxicity during intentional exposures do not specifically evaluate the contribution of endogenous photosensitizers. However, certain retinal diseases are characterized by abnormal accumulations of potential photosensitizers such as lipofuscin bisretinoids in the retinal pigment epithelium (RPE). We sought to determine these contributions by a numerical assessment of in-vivo photo-oxidative stress during irradiation of RPE lipofuscin.

Methods

Based on the literature, we calculated the retinal exposure levels, optical filtering of incident radiation by the ocular lens, media, photoreceptors, and RPE melanin, light absorption by lipofuscin, and photochemical effects in the RPE in two situations: exposure

SUBMITTER: Teussink MM 

PROVIDER: S-EPMC5325292 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature