The role of neuromedin U in adiposity regulation. Haplotype analysis in European children from the IDEFICS Cohort.

ABSTRACT:

Background and aims

Neuromedin U (NMU) is a hypothalamic neuropeptide with important roles in several metabolic processes, recently suggested as potential therapeutic target for obesity. We analysed the associations between NMU gene variants and haplotypes and body mass index (BMI) in a large sample of European children.

Methods and results

From a large European multi-center study on childhood obesity, 4,528 children (2.0-9.9 years, mean age 6.0±1.8 SD; boys 52.2%) were randomly selected, stratifying by age, sex and country, and genotyped for tag single nucleotide polymorphisms (SNPs; rs6827359, T:C; rs12500837, T:C; rs9999653,C:T) of NMU gene, then haplotypes were inferred. Regression models were applied to estimate the associations between SNPs or haplotypes and BMI as wel

SUBMITTER: Gianfagna F 

PROVIDER: S-EPMC5325300 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature