Systematic analysis of tumour cell-extracellular matrix adhesion identifies independent prognostic factors in breast cancer.

ABSTRACT: Tumour cell-extracellular matrix (ECM) interactions are fundamental for discrete steps in breast cancer progression. In particular, cancer cell adhesion to ECM proteins present in the microenvironment is critical for accelerating tumour growth and facilitating metastatic spread. To assess the utility of tumour cell-ECM adhesion as a means for discovering prognostic factors in breast cancer survival, here we perform a systematic phenotypic screen and characterise the adhesion properties of a panel of human HER2 amplified breast cancer cell lines across six ECM proteins commonly deregulated in breast cancer. We determine a gene expression signature that defines a subset of cell lines displaying impaired adhesion to laminin. Cells with impaired laminin adhesion showed an enrichment in genes a

SUBMITTER: Todd JR 

PROVIDER: S-EPMC5325338 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature