Non-targeted and targeted metabolomics approaches to diagnosing lung cancer and predicting patient prognosis.

ABSTRACT: Lung cancer is the most common cause of cancer death in China. We characterized metabolic alterations in lung cancer using two analytical platforms: a non-targeted metabolic profiling strategy based on proton nuclear magnetic resonance (1H-NMR) spectroscopy and a targeted metabolic profiling strategy based on rapid resolution liquid chromatography (RRLC). Changes in serum metabolite levels during oncogenesis were evaluated in 25 stage I lung cancer patients and matched healthy controls. We identified 25 metabolites that were differentially regulated between the lung cancer patients and matched controls. Of those, 16 were detected using the non-targeted approach and 9 were identified using the targeted approach. Both groups of metabolites could differentiate between lung cancer patients and

SUBMITTER: Zhang X 

PROVIDER: S-EPMC5325375 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature