Comparative profiling between primary colorectal carcinomas and metastases identifies heterogeneity on drug resistance.

ABSTRACT: Metastases cause recurrence and mortality for patients with colorectal carcinomas (CRC). In present study, we evaluated heterogeneity on drug resistance and its underlying mechanism between metastatic and primary CRC. Immunohistochemical results from clinical tissue microarray (TMA) suggested that the expression concordance rates of cancer stem cells (CSCs) and drug resistance relative proteins between lymph-node metastatic and primary CRC foci were low. The apoptotic and proliferation indexes in metastasis CRC specimens were decreased compared with primary. In vitro experimental results indicated that the migration and invasion abilities were upregulated in metastatic cells SW620 compared with primary cells SW480, the cellular efflux ability and WNT/β-catenin activity were also upregulate

SUBMITTER: Luo F 

PROVIDER: S-EPMC5325415 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature