Coupling CDH17 and CLDN18 markers for comprehensive membrane-targeted detection of human gastric cancer.

ABSTRACT: Patients with gastric cancer typically face gastrectomies even when few or no nodal metastases are reported. Current procedures poorly predict lymphatic metastases; thus, evaluation of target molecules expressed on cancer cell membranes is necessary for in vivo detection. However, marker development is limited by the intratumoral heterogeneity of gastric cancer cells. In this study, multiple gene expression arrays of 42 systemic normal tissue samples and 56 gastric cancer samples were used to investigate two adhesion molecules, cadherin 17 (CDH17) and claudin 18 (CLDN18), which are intestinal and gastric markers, respectively. Expression of CDH17 and CLDN18 was partially redundant, but overlapped in 50 of 56 cases (89.3%). Tissue microarrays constructed using primary lesions and nodal meta

SUBMITTER: Matsusaka K 

PROVIDER: S-EPMC5325433 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature