A phase I study of intratumoral ipilimumab and interleukin-2 in patients with advanced melanoma.

ABSTRACT:

Purpose

Intratumoral interleukin-2 (IL-2) is effective but does not generate systemic immunity. Intravenous ipilimumab produces durable clinical response in a minority of patients, with potentially severe toxicities. Circulating anti-tumor T cells activated by ipilimumab may differ greatly from tumor-infiltrating lymphocytes activated by intratumoral ipilimumab in phenotypes and functionality. The objective of this study was to primarily assess the safety of intratumoral ipilimumab/IL-2 combination and to obtain data on clinical efficacy.

Results

There was no dose limiting toxicity. While local response of injected lesions was observed in 67% patients (95% CI, 40%-93%), an abscopal response was seen in 89% (95% CI, 68%-100%). The overall response rate and clinical benefit ra

SUBMITTER: Ray A 

PROVIDER: S-EPMC5325451 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature