Beneficial effects of exercise on offspring obesity and insulin resistance are reduced by maternal high-fat diet.

ABSTRACT:

Scope

We investigated the long-term effects of maternal high-fat consumption and post-weaning exercise on offspring obesity susceptibility and insulin resistance.

Methods

C57BL/6J dams were fed either a high-fat (HFD, 40% kcal fat) or low-fat (LFD, 10% kcal fat) semi-synthetic diet during pregnancy and lactation. After weaning, male offspring of both maternal diet groups (mLFD; mHFD) received a LFD. At week 7, half of the mice got access to a running wheel (+RW) as voluntary exercise training. To induce obesity, all offspring groups (mLFD +/-RW and mHFD +/-RW) received HFD from week 15 until week 25.

Results

Compared to mLFD, mHFD offspring were more prone to HFD-induced body fat gain and exhibited an increased liver mass which was not due to increased hepatic triglyc

SUBMITTER: Kasch J 

PROVIDER: S-EPMC5325607 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature