Acute administration of acyl, but not desacyl ghrelin, decreases blood pressure in healthy humans.

ABSTRACT:

Objective

To compare the effects of acyl ghrelin (AG) and desacyl ghrelin (DAG) on blood pressure (BP), heart rate (HR) and other autonomic parameters in healthy humans and to elucidate the hormonal mechanisms through which AG could exert its cardiovascular effects.

Design

Seventeen healthy participants underwent frequent monitoring of systolic (sBP) and diastolic blood pressure (dBP), HR, respiratory rate (RR) and body surface temperature (Temp) during continuous infusion of AG, DAG, combined AG + DAG or saline control before and during an IV glucose tolerance test on 4 separate days. Plasma catecholamines, renin and aldosterone levels were also measured. Differences in outcome measures between treatment groups were assessed using mixed-model analysis.

Results

Compar

SUBMITTER: Zhang CJ 

PROVIDER: S-EPMC5325691 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature