Shared decision-making following disclosure of coronary heart disease genetic risk: results from a randomized clinical trial.

ABSTRACT: Whether disclosure of genetic risk for coronary heart disease (CHD) influences shared decision-making (SDM) regarding use of statins to reduce CHD risk is unknown. We randomized 207 patients, age 45-65 years, at intermediate CHD risk, and not on statins, to receive the 10-year risk of CHD based on conventional risk factors alone (n=103) or in combination with a genetic risk score (n=104). A genetic counselor disclosed this information followed by a physician visit for SDM regarding statin therapy. A novel decision aid was used in both encounters to disclose the CHD risk estimates and facilitate SDM regarding statin use. Patients reported their decision quality and physician visit satisfaction using validated surveys. There were no statistically significant differences between the two group

SUBMITTER: Jouni H 

PROVIDER: S-EPMC5325770 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature