Atrazine exposure elicits copy number alterations in the zebrafish genome.

ABSTRACT: Atrazine is an agricultural herbicide used throughout the Midwestern United States that frequently contaminates potable water supplies resulting in human exposure. Using the zebrafish model system, an embryonic atrazine exposure was previously reported to decrease spawning rates with an increase in progesterone and ovarian follicular atresia in adult females. In addition, alterations in genes associated with distinct molecular pathways of the endocrine system were observed in brain and gonad tissue of the adult females and males. Current hypotheses for mechanistic changes in the developmental origins of health and disease include genetic (e.g., copy number alterations) or epigenetic (e.g., DNA methylation) mechanisms. As such, in the current study we investigated whether an atrazine exposu

SUBMITTER: Wirbisky SE 

PROVIDER: S-EPMC5325771 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature