Ex vivo MRI transverse relaxation in community based older persons with and without Alzheimer's dementia.

ABSTRACT: Alterations of the transverse relaxation rate, R₂, measured using MRI, are observed in older persons with Alzheimer's (AD) dementia. However, the spatial pattern of these alterations and the degree to which they reflect the accumulation of common age-related neuropathologies are unknown. In this study, we characterized the profile of R₂ alterations in post-mortem brains of persons with clinical diagnosis of AD dementia and investigated how the profile differs after accounting for neuropathologic indices of AD, cerebral infarcts, Lewy body disease, hippocampal sclerosis and transactive response DNA-binding protein 43. Data came from 567 post-mortem brains donated by participants in two cohort studies of aging and dementia. R₂ was quantified using fast spin e

SUBMITTER: Yu L 

PROVIDER: S-EPMC5325779 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature