Assessment of Type I Interferon Signaling in Pediatric Inflammatory Disease.

ABSTRACT:

Purpose

Increased type I interferon is considered relevant to the pathology of a number of monogenic and complex disorders spanning pediatric rheumatology, neurology, and dermatology. However, no test exists in routine clinical practice to identify enhanced interferon signaling, thus limiting the ability to diagnose and monitor treatment of these diseases. Here, we set out to investigate the use of an assay measuring the expression of a panel of interferon-stimulated genes (ISGs) in children affected by a range of inflammatory diseases.

Design, setting, and participants

A cohort study was conducted between 2011 and 2016 at the University of Manchester, UK, and the Institut Imagine, Paris, France. RNA PAXgene blood samples and clinical data were collected from controls and sy

SUBMITTER: Rice GI 

PROVIDER: S-EPMC5325846 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature