Acute Rejection Increases Risk of Graft Failure and Death in Recent Liver Transplant Recipients.

ABSTRACT:

Background & aims

Acute rejection is detrimental to most transplanted solid organs, but is considered to be less of a consequence for transplanted livers. We evaluated risk factors for and outcomes after biopsy-proven acute rejection (BPAR) based on an analysis of a more recent national sample of recipients of liver transplants from living and deceased donors.

Methods

We analyzed data from the Adult-to-Adult Living Donor Liver Transplantation Cohort Study (A2ALL) from 2003 through 2014 as the exploratory cohort and the Scientific Registry of Transplant Recipients (SRTR) from 2005 through 2013 as the validation cohort. We examined factors associated with time to first BPAR using multivariable Cox regression or discrete-survival analysis. Competing risks methods were used to c

SUBMITTER: Levitsky J 

PROVIDER: S-EPMC5326609 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature