Diagnosis of subglottic stenosis in a rabbit model using long-range optical coherence tomography.

ABSTRACT:

Objectives/hypothesis

Current imaging modalities lack the necessary resolution to diagnose subglottic stenosis. The aim of this study was to use optical coherence tomography (OCT) to evaluate nascent subglottic mucosal injury and characterize mucosal thickness and structural changes using texture analysis in a simulated intubation rabbit model.

Study design

Prospective animal study in rabbits.

Methods

Three-centimeter-long sections of endotracheal tubes (ETT) were endoscopically placed in the subglottis and proximal trachea of New Zealand White rabbits (n = 10) and secured via suture. OCT imaging and conventional endoscopic video was performed just prior to ETT segment placement (day 0), immediately after tube removal (day 7), and 1 week later (day 14). OCT images wer

SUBMITTER: Ajose-Popoola O 

PROVIDER: S-EPMC5326617 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature