Follicular T Cells from smB^- Common Variable Immunodeficiency Patients Are Skewed Toward a Th1 Phenotype.

ABSTRACT: Germinal center follicular T helper (GCTfh) cells are essential players in the differentiation of B cells. Circulating follicular T helper (cTfh) cells share phenotypic and functional properties with GCTfh cells. Distinct subpopulations of cTfh with different helper capabilities toward B cells can be identified: cTfh1 (CXCR3⁺CCR6^-), cTfh2 (CXCR3^-CCR6^-), and cTfh17 (CXCR3^-CCR6⁺). Alterations in cTfh function and/or distribution have been associated with autoimmunity, infectious diseases, and more recently, with several monogenic immunodeficiencies. Common variable immunodeficiency (CVID) disease is the commonest symptomatic primary immunodeficiency with a genetic cause identified in only 2-10% of patients. Although a heteroge

SUBMITTER: Cunill V 

PROVIDER: S-EPMC5326800 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature