The Human Skeletal Muscle Proteome Project: a reappraisal of the current literature.

ABSTRACT: Skeletal muscle is a large organ that accounts for up to half the total mass of the human body. A progressive decline in muscle mass and strength occurs with ageing and in some individuals configures the syndrome of 'sarcopenia', a condition that impairs mobility, challenges autonomy, and is a risk factor for mortality. The mechanisms leading to sarcopenia as well as myopathies are still little understood. The Human Skeletal Muscle Proteome Project was initiated with the aim to characterize muscle proteins and how they change with ageing and disease. We conducted an extensive review of the literature and analysed publically available protein databases. A systematic search of peer-reviewed studies was performed using PubMed. Search terms included 'human', 'skeletal muscle', 'proteome', 'pro

SUBMITTER: Gonzalez-Freire M 

PROVIDER: S-EPMC5326819 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature