Tyrosine-Nitrated Proteins: Proteomic and Bioanalytical Aspects.

ABSTRACT:

Significance

"Nitroproteomic" is under active development, as 3-nitrotyrosine in proteins constitutes a footprint left by the reactions of nitric oxide-derived oxidants that are usually associated to oxidative stress conditions. Moreover, protein tyrosine nitration can cause structural and functional changes, which may be of pathophysiological relevance for human disease conditions. Biological protein tyrosine nitration is a free radical process involving the intermediacy of tyrosyl radicals; in spite of being a nonenzymatic process, nitration is selectively directed toward a limited subset of tyrosine residues. Precise identification and quantitation of 3-nitrotyrosine in proteins has represented a "tour de force" for researchers. Recent Advances: A small number of proteins are pr

SUBMITTER: Batthyany C 

PROVIDER: S-EPMC5326983 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature