MiR-21 deficiency inhibits osteoclast function and prevents bone loss in mice.

ABSTRACT: MicroRNAs emerge as critical post-transcriptional regulators in bone metabolism. We have previously reported in vitro that miR-21 promotes osteogenesis, while studies have also revealed miR-21 as a regulator of osteoclastogenesis and a promoter of osteoclast differentiation in vitro. However, in vivo data are still lacking in identifying skeletal function of miR-21, particularly its effects on osteoporosis. Here, using miR-21 knockout (miR-21^-/-) mice, we investigated effects of miR-21 on bone development, bone remodeling and bone loss. Unexpectedly, miR-21^-/- mice demonstrated normal skeletal phenotype in development and maintained osteoblastogenesis in vivo. Besides, miR-21^-/- mice showed increased receptor activator of nuclear factor κB ligand (RANKL) an

SUBMITTER: Hu CH 

PROVIDER: S-EPMC5327426 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature