Perfluorinated alkyl substances in serum of the southern Chinese general population and potential impact on thyroid hormones.

ABSTRACT: In this study, eight perfluorinated alkyl substances (PFASs) and five thyroid hormones (TSH, FT4, FT3, TGAb, and TMAb) were determined in 202 human serum samples of the general population of Guangdong, Guangxi and Hainan provinces in southern China. Σ₈PFASs concentrations ranged from 0.85 to 24.3 ng/mL with a mean value of 4.66 ng/mL. The PFASs composition profiles of human serum samples nearly make no difference at different locations. A significant increase was observed for ∑₈PFASs, PFOS, and PFHxS concentrations with age (p < 0.01). Gender-related differences were found; PFOS, PFHxS, PFBS, and PFOA levels were higher in males (p < 0.05), and the mean concentration of ∑₈PFASs was 1.5 times greater in males (6.02 ng/mL) than in females (4.15 ng/mL). PFOS a

SUBMITTER: Li Y 

PROVIDER: S-EPMC5327476 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature